Career Scientist Mayo Clinic Phoenix, Arizona, United States
This presentation will explore the relationship between migraine and increased risk for major adverse cardiovascular events (MACE), including stroke. Prior population-based and clinical studies that have established this association, with particular focus on migraine with aura will be summarized. The methodology used to interrogate the Mayo Clinic electronic health records, including migraine and MACE cohort identification through ICD codes, clinical notes, imaging findings, and medication records will be described. Data from the Mayo Clinic and the All of Us Research Program showing elevated risk of ischemic and hemorrhagic stroke, as well as MACE, in individuals with migraine will be presented. This presentation will also highlight how integrating migraine-specific features, including white matter hyperintensities on MRI, can improve traditional cardiovascular risk prediction models.
Learning Objectives:
Review prior population-based and clinical studies demonstrating an increased risk of major adverse cardiovascular events (MACE) among individuals with migraine, specifically among those with migraine with aura.
Outline the strategy used to query the Mayo Clinic electronic medical record system, including cohort identification criteria for migraine and MACE using ICD codes, clinical notes, imaging, and medication records.
Present key results about the incidence of MACE in patients with migraine. Explore the implications of these results for risk stratification and consider how these data may inform personalized prevention strategies in patients with migraine.
